Liquid Plate Sealer is a stabilizer for coated antibodies and antigens on polystyrene or glass surfaces such as coated ELISA plates, immunochromatographic test strips (lateral flow assays), affinity chromatography columns, protein arrays and other applications. After immobilization of the antibodies or antigens and blocking, Liquid Plate Sealer seals the plates with a uniform, highly soluble stabilizing layer without affecting the assay. Due to the solubility, samples can be added to the stabilized surface without the need for an additional washing step after storage. When stored dry at 2-8°C, the coated molecules' shelf life is extended to 1-3 years. Most stabilized plates can also be stored dry at ambient temperature for several months without a loss in activity. Liquid Plate Sealer greatly improves the assay performance by providing critical stability to the biological components.